Slugging It out: Fine Tuning the p53-PUMA Death Connection
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چکیده
منابع مشابه
Slugging It out: Fine Tuning the p53-PUMA Death Connection
In response to DNA damage, the tumor suppressor p53 elicits a complex cellular response. In this issue of Cell, Wu et al. (2005) show that the transcription factor SLUG is induced by p53 and protects hematopoietic progenitor cells from apoptosis triggered by DNA damage. SLUG exerts this protective role by repressing Puma, a proapoptotic target of p53. PUMA is also a key coordinator of apoptosis...
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Most cancer treatments exploit the hypersensitivity of rapidly dividing tumor cells to DNA damage, largely reflecting problems with replicating damaged DNA templates. Many cancer chemotherapeutics directly damage DNA, and most types of DNA damage block replication forks. Other classes of chemotherapeutics include antimetabolites that reduce nucleotide pools and starve DNA polymerases or directl...
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Multiple structural, biochemical and in vivo studies have solidified the role that histone acetyltransferases (HATs) play in regulation of the p53 pathway. 1 HATs are known to modulate p53 functions in many ways, from regulating its stability to promoting acetyla-tion-dependent interactions with DnA as well as various co-factors and chromatin modi-fiers. 1 Of these, p300, CBP, PCAF and Tip60 ar...
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ژورنال
عنوان ژورنال: Cell
سال: 2005
ISSN: 0092-8674
DOI: 10.1016/j.cell.2005.11.003